Lysergamides are a class of organic compounds that are structurally related to the alkaloid LSD (lysergic acid diethylamide). They share a common core structure known as a lysergic acid amide. Lysergamides are known for their psychedelic and hallucinogenic effects, similar to LSD.

LSD, the most well-known lysergamide, was first synthesized by Albert Hofmann in the 1930s and gained popularity as a recreational drug in the 1960s during the counterculture movement. LSD and other lysergamides interact with serotonin receptors in the brain, particularly the 5-HT2A receptor, leading to profound alterations in perception, cognition, and mood.

Apart from LSD, there are other lysergamides that have been synthesized and studied, including analogs and derivatives. Some examples include AL-LAD, ETH-LAD, 1P-LSD, and ALD-52. These compounds are often sold as research chemicals or designer drugs and may have varying degrees of potency and effects.

Similar to tryptamines, lysergamides have a complex legal status in many countries. They are generally classified as controlled substances due to their psychoactive properties and potential for misuse. Possession, production, and distribution of lysergamides may be subject to legal restrictions and penalties. As with any psychoactive substance, it is important to prioritize safety, respect legal regulations, and consider potential risks before using lysergamides.

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